Hydrogen Deuterium Exchange (HDX)
Mass Spectrometry (MS)
Instrumentation
We use mass spectrometers from the Waters Corporation. In collaboration with Waters, we developed an instrumental system for HDX MS. Our laboratory is a Waters Corporation Center of Innovation.



The Waters HDX MS system is summarized in the following video:
Current Mass Spectrometers

SELECT SERIES Cyclic IMS
Electrospray quadrupole, cyclic ion-mobility MS/MS, high-resolution time-of-flight
DETAILS

Synapt XS
Electrospray quadrupole, stepwave XS, ion-mobility MS/MS, extended TOF
DETAILS

Synapt G2-Si #1
Electrospray quadrupole, ion-mobility MS/MS, high-resolution time-of-flight
DETAILS

Synapt G2-Si #2
Electrospray quadrupole, ion-mobility MS/MS, high-resolution time-of-flight
DETAILS

Xevo G2 QTof
Electrospray, MS/MS, Time-of-Flight
DETAILS
Chromatography Instrumentation and Robotics

Multiple UPLC systems

UPLCs for HDX MS
based on this publication

LEAP H/D-X PAL
Custom HDX sample prep robot